My answer is based upon my current company, which is a very low-tech, locally-focused healthcare services company. In that context, at least, I would do these things differently if I were starting it over again:
1) Hire a great salesperson ("great" depends on a lot of factors, which would be different from one case to the next) from the beginning.
2) Focus on profitability. "Happiness is positive cash flow, all else will come later".
3) Build a well-grounded strategic plan, and track your performance against it often, adjusting course as needed and paying CLOSE attention to the details. Be very honest with yourself about where you are succeeding and where you are not.
4) Hire slowly and carefully. Fire quickly when realize that you've made a mistake in hiring. Get it over with and move on.