I've got an answer for this, or at least... I hope to have an answer, that is 'No'. But since I'm a newcomer with very poor experience in this wonderful world that is 'starting up', I'd like to have your feedback on this.
Italy is a difficult country for little software vendor startups for a lot of reasons including people mentality (except for some great ideas like balsamiq, prossimaisola.it, funambol and the mindthebridge initiative).
In my opinion, if starting up with a software product to be released using the Internet (as web app or also as desktop app) it's not so relevant from where you write the code. Of course if you stay focused and if you aren't influenced by a negative ecosystem.
What do you think about that?