This 1.5 factor is independent of the 3x per year number. His point is that in order to calculate the expense of a new hire, you need to multiply their base salary by 1.5x. This gives you salary + overhead number that you can then use to calculate how much that person costs. Once you have the cost of that person, you can then use that to calculate the return on that person and how much "equity" you give up (since you are burning through cash to pay someone and you would have to raise that much more).
He does run through an example (reproduced below):
"Let's run through an example. Suppose the company wants to make a "profit" of 50% on the new hire mentioned above. So subtract a third from 16.7% and we have 11.1% as his "retail" price. Suppose further that he's going to cost $60k a year in salary and overhead, x 1.5 = $90k total. If the company's valuation is $2 million, $90k is 4.5%. 11.1% - 4.5% = an offer of 6.6%."
In the example above, the stock % for the new hire is worth 11.1%. The salary cost is another 4.5%. When you subtract that, you get 6.6%, which is the amount of the company you give away in equity, at that evaluation, to make a stock "profit" of 50%.